Project Objectives
CSFV_goDIVA
Project Objectives
The objectives of the CSFV_goDIVA project are:- 1. Standardization of newly developed diagnostic methods applicable to domestic pigs and in wild boar
- 2. Development and validation of new methods for the easy selection of suspicious animals (e.g. using thermographic infrared technology)
- 3. Molecular epidemiology for a better risk analyses
- 4. Final development and testing of the latest (3rd generation) modified live CSFV marker vaccines and accompanying DIVA diagnostics
- 5. New methods for the easy oral application of the vaccine
- 6. Role and pathogenesis of CSF virus reservoirs
- 7. Validation of the newly developed strategies including an epidemiological modelling
- 8. Exploration of alternative methods of suppression of viral replication.
In order to achieve the goals set, the project is divided into 15 Work Packages (WP) grouped into 5 major Tasks. The objectives for the individual Work Packages are listed below.
| Task A. Recent developments in new generation live marker vaccines and molecular diagnostic tools | |
|---|---|
| WP 1 | Selection of a final live vaccine candidate |
| WP 2 | Adaptation and establishment of live marker vaccine to industry scale production |
| WP 3 | Lab and field trials in view of the registration of the 3rd generation vaccine |
| WP 4 | New methods for the easy oral application of the vaccine |
| WP 5 | Field trial on wild boars, including baiting. Data collection/evaluation on wild boar vaccination |
| Task B. Epidemiology | |
| WP 6 | Comparative evaluation of classic and alternative control strategies in domestic pigs based on economic analysis of CSF-spread model |
| WP 7 | Model based analysis of field data on CSFV transmission/persistence in the wild |
| WP 8 | Descriptive epidemiology in back yard pigs of classical swine fever |
| WP 9 | Early warning systems of CSF and surveillance in domestic pigs and wild boar |
| WP 10 | Explorative Molecular epidemiology (Distribution, clustering, species specificity) |
| Task C. Improve detection and diagnosis + validation (including DIVA diagnostic tools) | |
| WP 11 | Evaluation of currently available antibody ELISAs for DIVA purposes. Characterisation of monoclonal antibodies and antigens for potential use in ELISAs. |
| WP 12 | Development of alternative new methods for DIVA detection of nucleic acids and antibodies for laboratory use and for on-site testing of domestic pigs and wild boars |
| WP 13 | Development and validation of new methods for the easy selection of suspicious animals (infra-red thermographic camera) and sample reduction (Pooling) |
| Task D. Improve knowledge on immunological reaction directly related to vaccine improvement | |
| WP 14 | Improve knowledge on immunological reactions directly related to vaccine improvement |
| Task E. Alternative methods of suppression of viral replication | |
| WP 15 | Exploration of alternative methods of suppression of viral replication |
