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Potential impact
This proposal aims at the development of an epidemiological and economic model for CSF eradication in wild boar and at providing a basis for the development of a new generation of live marker vaccines for the control of an animal disease that has caused huge losses within the European community and seems to become endemic in some wild boar populations. This wildlife species is a reservoir of this pathogen for farm animals. The innovation of this approach is that it will provide for the first time a scientific basis for the control of CSF in wild boar, by describing and comparing the available results and the new acquired knowledge concerning wild boar and CSF epidemiology. The involvement of the new developed European database will enforce the exploitation of this database and the results of the research of the present proposal. The advantage of this approach is that it can be used for policy making as well in a non-vaccination as a vaccination strategy, because the models will support new strategies and acquire. Furthermore a better understanding of CSF epidemiology in wild boar will be acquired and as a consequence methods suitable for avoiding this transmission will be developed.
The actual vaccination strategy in wild boar as described before is based on the C-strain. Since a C-strain vaccine is used serological monitoring of the wild boar population in order to detect infection becomes impossible. Also the threat of carrier animals remains.
Up to now, no marker vaccines have been tested for the oral immunization of wild boar. Since inactivated preparations (e .g. E2 subunit vaccines) and DNA vaccines may not be suitable to induce a protective immunity after oral application, modified live marker vaccines or Disabled Infectious Single Cycle (DISC) vaccines could be potent candidates for the oral CSFV vaccination of wild boar.
Therefore, improved immunization procedures as well as new vaccines are recommended by the Scientific Committee on Animal health and Animal Welfare (SCAHAW). "New procedures and novel vaccines should allow the efficient immunization of young animals, and should enable a discrimination of vaccinated from infected wild boar (marker vaccines)" Are the second important innovation of this proposal.
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